Drug interactions
Clobazam + Dimenhydrinate
Severity: Moderate
Clobazam and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine, and a sedating antihistamine can increase drowsiness and psychomotor impairment. Respiratory depression is possible, particularly at higher doses or with other depressants.
What this interaction means in plain words
Clobazam and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive CNS depression via GABA-A modulation and H1 antagonism.
What to do
Monitor sedation and respiratory function, and use the lowest effective doses. Advise patients to avoid alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Dimenhydrinate?
MediHelp rates the interaction as moderate. Clobazam and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine, and a sedating antihistamine can increase drowsiness and psychomotor impairment. Respiratory depression is possible, particularly at higher doses or with other depressants.
How serious is the interaction between Clobazam and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function, and use the lowest effective doses. Advise patients to avoid alcohol and driving until the response is known.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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