Drug interactions
Clobazam + Imipramine
Severity: Moderate
Clobazam and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam, through its active metabolite, can weakly inhibit CYP2D6 and raise imipramine and desipramine levels. Both drugs also depress the CNS, so sedation and psychomotor impairment may be increased. Tricyclics can also lower the seizure threshold, which matters in patients treated for epilepsy.
What this interaction means in plain words
Clobazam and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by clobazam plus additive CNS depression.
What to do
Monitor for sedation and tricyclic adverse effects, and reduce the imipramine dose if needed. Monitor seizure control in patients with epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Imipramine?
MediHelp rates the interaction as moderate. Clobazam and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam, through its active metabolite, can weakly inhibit CYP2D6 and raise imipramine and desipramine levels. Both drugs also depress the CNS, so sedation and psychomotor impairment may be increased. Tricyclics can also lower the seizure threshold, which matters in patients treated for epilepsy.
How serious is the interaction between Clobazam and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and tricyclic adverse effects, and reduce the imipramine dose if needed. Monitor seizure control in patients with epilepsy.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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