Drug interactions
Clobazam + Irinotecan
Severity: Minor
Clobazam and Irinotecan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP3A4 inducer, which could modestly lower irinotecan and SN-38 exposure. The clinical effect is likely small, unlike strong enzyme-inducing anticonvulsants.
What this interaction means in plain words
Clobazam and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Irinotecan belongs to Oncology.
Why it happens
Weak CYP3A4 induction may increase irinotecan oxidative clearance.
What to do
No dose change is generally needed; monitor for reduced response to irinotecan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Irinotecan?
MediHelp rates the interaction as minor. Clobazam and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam is a weak CYP3A4 inducer, which could modestly lower irinotecan and SN-38 exposure. The clinical effect is likely small, unlike strong enzyme-inducing anticonvulsants.
How serious is the interaction between Clobazam and Irinotecan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for reduced response to irinotecan.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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