Drug interactions
Clobazam + Levonorgestrel
Severity: Moderate
Clobazam and Levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP3A4 inducer and may reduce hormonal contraceptive effectiveness, particularly with oral or emergency levonorgestrel. Intrauterine systems act mainly locally and are less affected.
What this interaction means in plain words
Clobazam and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Levonorgestrel belongs to Endocrine.
Why it happens
Weak CYP3A4 induction by clobazam increases levonorgestrel clearance.
What to do
With oral levonorgestrel, add a non-hormonal contraceptive method. An intrauterine system generally remains reliable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Levonorgestrel?
MediHelp rates the interaction as moderate. Clobazam and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak CYP3A4 inducer and may reduce hormonal contraceptive effectiveness, particularly with oral or emergency levonorgestrel. Intrauterine systems act mainly locally and are less affected.
How serious is the interaction between Clobazam and Levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With oral levonorgestrel, add a non-hormonal contraceptive method. An intrauterine system generally remains reliable.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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