Drug interactions
Clobazam + Lorazepam
Severity: Moderate
Clobazam and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so combined use duplicates therapy and increases sedation, ataxia and respiratory depression risk. Tolerance and dependence liabilities are also additive.
What this interaction means in plain words
Clobazam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A receptor positive modulation.
What to do
Use together only when clinically justified, such as in refractory seizures, and monitor sedation and respiratory function with the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Lorazepam?
MediHelp rates the interaction as moderate. Clobazam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so combined use duplicates therapy and increases sedation, ataxia and respiratory depression risk. Tolerance and dependence liabilities are also additive.
How serious is the interaction between Clobazam and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when clinically justified, such as in refractory seizures, and monitor sedation and respiratory function with the lowest effective doses.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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