Drug interactions
Clobazam + Lorlatinib
Severity: Moderate
Clobazam and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak to moderate CYP3A4 inducer and may lower lorlatinib exposure, potentially reducing antitumor efficacy. Lorlatinib is itself associated with hepatotoxicity and induction-related changes in liver enzymes, so the combination needs attention.
What this interaction means in plain words
Clobazam and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
Clobazam induces CYP3A4, increasing the metabolism of lorlatinib.
What to do
Prefer an alternative anticonvulsant or anxiolytic if feasible. If the combination is needed, monitor ALT, AST and bilirubin and watch for loss of lorlatinib response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Lorlatinib?
MediHelp rates the interaction as moderate. Clobazam and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak to moderate CYP3A4 inducer and may lower lorlatinib exposure, potentially reducing antitumor efficacy. Lorlatinib is itself associated with hepatotoxicity and induction-related changes in liver enzymes, so the combination needs attention.
How serious is the interaction between Clobazam and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative anticonvulsant or anxiolytic if feasible. If the combination is needed, monitor ALT, AST and bilirubin and watch for loss of lorlatinib response.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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