Drug interactions
Clobazam + Nortriptyline
Severity: Moderate
Clobazam and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam adds CNS depression to nortriptyline, which can increase sedation and, rarely, respiratory depression. Clobazam's metabolite is a weak CYP2D6 inhibitor and may raise nortriptyline concentrations.
What this interaction means in plain words
Clobazam and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depression, and weak CYP2D6 inhibition by clobazam raising nortriptyline levels.
What to do
Monitor sedation and tricyclic adverse effects, and reduce the nortriptyline dose if toxicity appears. Consider checking nortriptyline concentrations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Nortriptyline?
MediHelp rates the interaction as moderate. Clobazam and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam adds CNS depression to nortriptyline, which can increase sedation and, rarely, respiratory depression. Clobazam's metabolite is a weak CYP2D6 inhibitor and may raise nortriptyline concentrations.
How serious is the interaction between Clobazam and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and tricyclic adverse effects, and reduce the nortriptyline dose if toxicity appears. Consider checking nortriptyline concentrations.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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