Drug interactions
Clobazam + Oxazepam
Severity: Moderate
Clobazam and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so using them together duplicates pharmacologic effect and increases sedation, cognitive impairment and respiratory depression. Tolerance and dependence risk may also rise.
What this interaction means in plain words
Clobazam and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Avoid unnecessary duplication of benzodiazepines; if both are required, use the lowest doses and monitor sedation and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Oxazepam?
MediHelp rates the interaction as moderate. Clobazam and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so using them together duplicates pharmacologic effect and increases sedation, cognitive impairment and respiratory depression. Tolerance and dependence risk may also rise.
How serious is the interaction between Clobazam and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary duplication of benzodiazepines; if both are required, use the lowest doses and monitor sedation and respiratory status.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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