Drug interactions
Clobazam + Pantoprazole
Severity: Minor
Clobazam and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam's active metabolite N-desmethylclobazam is cleared by CYP2C19, and pantoprazole is a weak CYP2C19 inhibitor. Exposure to the active metabolite may rise slightly, with possible added sedation.
What this interaction means in plain words
Clobazam and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP2C19 inhibition by pantoprazole reduces clearance of N-desmethylclobazam.
What to do
No routine change is needed. Monitor for sedation or drowsiness and reduce the clobazam dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Pantoprazole?
MediHelp rates the interaction as minor. Clobazam and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam's active metabolite N-desmethylclobazam is cleared by CYP2C19, and pantoprazole is a weak CYP2C19 inhibitor. Exposure to the active metabolite may rise slightly, with possible added sedation.
How serious is the interaction between Clobazam and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for sedation or drowsiness and reduce the clobazam dose if these occur.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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