Drug interactions
Clobazam + Siponimod
Severity: Moderate
Clobazam and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP3A4 inducer and may modestly lower siponimod exposure. The clinical relevance is limited but greater in CYP2C9*1/*3 or *2/*3 patients.
What this interaction means in plain words
Clobazam and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases siponimod metabolism.
What to do
Monitor for reduced MS control, and avoid in CYP2C9*1/*3 and *2/*3 patients when an alternative anticonvulsant exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Siponimod?
MediHelp rates the interaction as moderate. Clobazam and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak CYP3A4 inducer and may modestly lower siponimod exposure. The clinical relevance is limited but greater in CYP2C9*1/*3 or *2/*3 patients.
How serious is the interaction between Clobazam and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced MS control, and avoid in CYP2C9*1/*3 and *2/*3 patients when an alternative anticonvulsant exists.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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