Drug interactions
Clobazam + Tolterodine
Severity: Minor
Clobazam and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP2D6 inhibitor and may modestly raise levels of tolterodine, a CYP2D6 substrate. The effect is typically small but could increase anticholinergic adverse effects. Clobazam also adds sedation and cognitive effects.
What this interaction means in plain words
Clobazam and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Weak inhibition of CYP2D6-mediated tolterodine metabolism.
What to do
Monitor for anticholinergic effects and drowsiness. Reduce the tolterodine dose if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Tolterodine?
MediHelp rates the interaction as minor. Clobazam and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam is a weak CYP2D6 inhibitor and may modestly raise levels of tolterodine, a CYP2D6 substrate. The effect is typically small but could increase anticholinergic adverse effects. Clobazam also adds sedation and cognitive effects.
How serious is the interaction between Clobazam and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and drowsiness. Reduce the tolterodine dose if adverse effects develop.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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