Drug interactions
Clofazimine + Entrectinib
Severity: Major
Clofazimine and Entrectinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lengthen the QTc interval, so concurrent use raises the risk of torsades de pointes and sudden cardiac death. The risk is greater with electrolyte disturbance, bradycardia or heart disease.
What this interaction means in plain words
Clofazimine and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clofazimine belongs to Anti Bacterial; Entrectinib belongs to Oncology.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Avoid combining them if an alternative exists. If both are needed, check a baseline ECG and electrolytes, correct abnormalities, and monitor the ECG during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clofazimine
Other interactions of Entrectinib
Frequently asked questions
Can I take Clofazimine with Entrectinib?
MediHelp rates the interaction as major. Clofazimine and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QTc interval, so concurrent use raises the risk of torsades de pointes and sudden cardiac death. The risk is greater with electrolyte disturbance, bradycardia or heart disease.
How serious is the interaction between Clofazimine and Entrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them if an alternative exists. If both are needed, check a baseline ECG and electrolytes, correct abnormalities, and monitor the ECG during treatment.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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