Drug interactions
Clofazimine + Etrasimod
Severity: Moderate
Clofazimine and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently slow heart rate and conduction, and clofazimine prolongs the QT interval. Bradycardia combined with QT prolongation raises the risk of torsades de pointes.
What this interaction means in plain words
Clofazimine and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofazimine belongs to Anti Bacterial; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive effects: etrasimod-induced bradycardia with clofazimine-related QT prolongation.
What to do
Obtain a baseline ECG before starting etrasimod and consider cardiology advice. Monitor heart rate and QTc, and correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofazimine
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Clofazimine with Etrasimod?
MediHelp rates the interaction as moderate. Clofazimine and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can transiently slow heart rate and conduction, and clofazimine prolongs the QT interval. Bradycardia combined with QT prolongation raises the risk of torsades de pointes.
How serious is the interaction between Clofazimine and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting etrasimod and consider cardiology advice. Monitor heart rate and QTc, and correct electrolyte disturbances.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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