Drug interactions
Clofazimine + Glasdegib
Severity: Major
Clofazimine and Glasdegib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, and used together they raise the likelihood of clinically important arrhythmias including torsades de pointes. Patients with electrolyte disturbances or cardiac disease are at greater risk.
What this interaction means in plain words
Clofazimine and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clofazimine belongs to Anti Bacterial; Glasdegib belongs to Oncology.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Prefer an alternative to one agent. If both are needed, monitor ECG and electrolytes more often and replete potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clofazimine
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Clofazimine with Glasdegib?
MediHelp rates the interaction as major. Clofazimine and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, and used together they raise the likelihood of clinically important arrhythmias including torsades de pointes. Patients with electrolyte disturbances or cardiac disease are at greater risk.
How serious is the interaction between Clofazimine and Glasdegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to one agent. If both are needed, monitor ECG and electrolytes more often and replete potassium and magnesium.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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