Drug interactions
Clofazimine + Ivosidenib
Severity: Major
Clofazimine and Ivosidenib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib causes dose-related QT prolongation, and clofazimine has similar effects. Together they increase the risk of torsades de pointes and other serious ventricular arrhythmias.
What this interaction means in plain words
Clofazimine and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clofazimine belongs to Anti Bacterial; Ivosidenib belongs to Oncology.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Avoid the combination or replace one drug. If unavoidable, monitor ECGs and electrolytes frequently and interrupt or reduce ivosidenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clofazimine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Clofazimine with Ivosidenib?
MediHelp rates the interaction as major. Clofazimine and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib causes dose-related QT prolongation, and clofazimine has similar effects. Together they increase the risk of torsades de pointes and other serious ventricular arrhythmias.
How serious is the interaction between Clofazimine and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or replace one drug. If unavoidable, monitor ECGs and electrolytes frequently and interrupt or reduce ivosidenib if QTc becomes markedly prolonged.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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