Drug interactions
Clofazimine + Lofexidine
Severity: Moderate
Clofazimine and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clofazimine and lofexidine each have QT-prolonging potential, so combined use may increase the likelihood of serious ventricular arrhythmias. Lofexidine also causes bradycardia and hypotension, which add to proarrhythmic risk.
What this interaction means in plain words
Clofazimine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofazimine belongs to Anti Bacterial; Lofexidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Check a baseline ECG and monitor QTc, heart rate and blood pressure during co-therapy. Correct hypokalemia and hypomagnesemia, and avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofazimine
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Clofazimine with Lofexidine?
MediHelp rates the interaction as moderate. Clofazimine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clofazimine and lofexidine each have QT-prolonging potential, so combined use may increase the likelihood of serious ventricular arrhythmias. Lofexidine also causes bradycardia and hypotension, which add to proarrhythmic risk.
How serious is the interaction between Clofazimine and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc, heart rate and blood pressure during co-therapy. Correct hypokalemia and hypomagnesemia, and avoid adding further QT-prolonging drugs.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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