Drug interactions
Clofazimine + Pitolisant
Severity: Major
Clofazimine and Pitolisant: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can prolong the QT interval modestly, and clofazimine also has this property. Using both increases the risk of ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Clofazimine and Pitolisant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clofazimine belongs to Anti Bacterial; Pitolisant belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Avoid the combination when feasible. If both are needed, obtain baseline and follow-up ECGs and maintain normal potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clofazimine
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Clofazimine with Pitolisant?
MediHelp rates the interaction as major. Clofazimine and Pitolisant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pitolisant can prolong the QT interval modestly, and clofazimine also has this property. Using both increases the risk of ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Clofazimine and Pitolisant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when feasible. If both are needed, obtain baseline and follow-up ECGs and maintain normal potassium and magnesium.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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