Drug interactions
Clomipramine + Clonazepam
Severity: Moderate
Clomipramine and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs can increase sedation, dizziness and cognitive impairment. Clomipramine may also lower the seizure threshold, which is relevant when clonazepam is used for epilepsy.
What this interaction means in plain words
Clomipramine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and the antihistaminic and anticholinergic effects of clomipramine.
What to do
Monitor for oversedation and, in epilepsy, for change in seizure control. Use the lowest effective doses and counsel about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Clonazepam?
MediHelp rates the interaction as moderate. Clomipramine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together these drugs can increase sedation, dizziness and cognitive impairment. Clomipramine may also lower the seizure threshold, which is relevant when clonazepam is used for epilepsy.
How serious is the interaction between Clomipramine and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and, in epilepsy, for change in seizure control. Use the lowest effective doses and counsel about driving.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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