Drug interactions
Clomipramine + Degarelix
Severity: Moderate
Clomipramine and Degarelix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy, including degarelix, can prolong the QT interval, and clomipramine has similar effects. Combined use may increase the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Clomipramine and Degarelix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Degarelix belongs to Endocrine.
Why it happens
Additive QT interval prolongation.
What to do
Review baseline ECG and electrolytes, and monitor the QTc during therapy. Consider an alternative antidepressant in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Clomipramine with Degarelix?
MediHelp rates the interaction as moderate. Clomipramine and Degarelix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy, including degarelix, can prolong the QT interval, and clomipramine has similar effects. Combined use may increase the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Clomipramine and Degarelix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and electrolytes, and monitor the QTc during therapy. Consider an alternative antidepressant in patients with other QT risk factors.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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