Drug interactions
Clomipramine + Diazepam
Severity: Moderate
Clomipramine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is sedating and can add to the CNS depressant effects of diazepam, causing drowsiness and impaired performance. Diazepam may also be used with it for anxiety, so the combination is common and needs monitoring.
What this interaction means in plain words
Clomipramine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression from antihistaminic and anticholinergic effects of the tricyclic with GABA-A potentiation.
What to do
Monitor for oversedation, psychomotor impairment and anticholinergic effects, and advise against driving until stable. Adjust doses downward if sedation persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Diazepam?
MediHelp rates the interaction as moderate. Clomipramine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is sedating and can add to the CNS depressant effects of diazepam, causing drowsiness and impaired performance. Diazepam may also be used with it for anxiety, so the combination is common and needs monitoring.
How serious is the interaction between Clomipramine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, psychomotor impairment and anticholinergic effects, and advise against driving until stable. Adjust doses downward if sedation persists.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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