Drug interactions
Clomipramine + Doxylamine
Severity: Moderate
Clomipramine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating, anticholinergic antihistamine. With clomipramine it can cause pronounced drowsiness and anticholinergic effects such as confusion, dry mouth and urinary retention.
What this interaction means in plain words
Clomipramine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Doxylamine belongs to Respiratory.
Why it happens
Additive anticholinergic and CNS depressant effects.
What to do
Avoid regular combined use, especially in the elderly, and monitor for sedation and anticholinergic effects. Advise against driving after doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Doxylamine
Frequently asked questions
Can I take Clomipramine with Doxylamine?
MediHelp rates the interaction as moderate. Clomipramine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating, anticholinergic antihistamine. With clomipramine it can cause pronounced drowsiness and anticholinergic effects such as confusion, dry mouth and urinary retention.
How serious is the interaction between Clomipramine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular combined use, especially in the elderly, and monitor for sedation and anticholinergic effects. Advise against driving after doses.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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