Drug interactions
Clomipramine + Ezogabine
Severity: Major
Clomipramine and Ezogabine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, and clomipramine can also prolong QT, so the combination may increase arrhythmia risk. Ezogabine also causes dizziness, somnolence and urinary retention that may add to tricyclic effects.
What this interaction means in plain words
Clomipramine and Ezogabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Ezogabine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive CNS and urinary retention effects.
What to do
Monitor ECG and electrolytes, and avoid the combination in patients with other QT risk factors. Monitor for urinary retention and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Clomipramine with Ezogabine?
MediHelp rates the interaction as major. Clomipramine and Ezogabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ezogabine has been associated with QT prolongation, and clomipramine can also prolong QT, so the combination may increase arrhythmia risk. Ezogabine also causes dizziness, somnolence and urinary retention that may add to tricyclic effects.
How serious is the interaction between Clomipramine and Ezogabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and avoid the combination in patients with other QT risk factors. Monitor for urinary retention and sedation.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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