Drug interactions
Clomipramine + Fesoterodine
Severity: Moderate
Clomipramine and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine has strong anticholinergic properties that add to those of fesoterodine. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, and may worsen tachycardia.
What this interaction means in plain words
Clomipramine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects; clomipramine may also be a CYP2D6 substrate with minor kinetic effects.
What to do
Monitor for anticholinergic adverse effects, especially urinary retention and constipation, and consider dose reduction or an alternative if these develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Fesoterodine?
MediHelp rates the interaction as moderate. Clomipramine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine has strong anticholinergic properties that add to those of fesoterodine. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, and may worsen tachycardia.
How serious is the interaction between Clomipramine and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially urinary retention and constipation, and consider dose reduction or an alternative if these develop.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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