Drug interactions
Clomipramine + Fingolimod
Severity: Major
Clomipramine and Fingolimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod can cause bradycardia and QT prolongation after the first dose, and clomipramine also affects cardiac conduction and QT. Combined use may increase the risk of serious arrhythmia.
What this interaction means in plain words
Clomipramine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Fingolimod belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with fingolimod-induced bradycardia increasing proarrhythmic risk.
What to do
Obtain an ECG before starting and monitor heart rate and ECG during fingolimod initiation. Consider an alternative antidepressant if QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Clomipramine with Fingolimod?
MediHelp rates the interaction as major. Clomipramine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod can cause bradycardia and QT prolongation after the first dose, and clomipramine also affects cardiac conduction and QT. Combined use may increase the risk of serious arrhythmia.
How serious is the interaction between Clomipramine and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting and monitor heart rate and ECG during fingolimod initiation. Consider an alternative antidepressant if QTc is prolonged.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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