Drug interactions
Clomipramine + Frovatriptan
Severity: Moderate
Clomipramine and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, so combined use may rarely lead to serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. Clomipramine is a potent serotonin reuptake inhibitor, which makes this more relevant than with other tricyclics.
What this interaction means in plain words
Clomipramine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects: serotonin reuptake inhibition by clomipramine plus 5-HT1B/1D agonism by frovatriptan.
What to do
Counsel the patient to report agitation, tremor, sweating or fever promptly. Stop the triptan and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Clomipramine with Frovatriptan?
MediHelp rates the interaction as moderate. Clomipramine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, so combined use may rarely lead to serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. Clomipramine is a potent serotonin reuptake inhibitor, which makes this more relevant than with other tricyclics.
How serious is the interaction between Clomipramine and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating or fever promptly. Stop the triptan and treat if serotonin syndrome is suspected.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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