Drug interactions
Clomipramine + Galantamine
Severity: Moderate
Clomipramine and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine has strong anticholinergic activity, which opposes the cholinergic effect of galantamine used for dementia. The two drugs may blunt each other, reducing cognitive benefit. Galantamine may also add to bradycardia risk and clomipramine can cause confusion in elderly patients.
What this interaction means in plain words
Clomipramine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Galantamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between cholinesterase inhibition and muscarinic receptor blockade by the tricyclic antidepressant.
What to do
Avoid clomipramine in dementia patients where possible and choose a less anticholinergic antidepressant such as an SSRI. If combined, monitor cognition, heart rate and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Clomipramine with Galantamine?
MediHelp rates the interaction as moderate. Clomipramine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine has strong anticholinergic activity, which opposes the cholinergic effect of galantamine used for dementia. The two drugs may blunt each other, reducing cognitive benefit. Galantamine may also add to bradycardia risk and clomipramine can cause confusion in elderly patients.
How serious is the interaction between Clomipramine and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid clomipramine in dementia patients where possible and choose a less anticholinergic antidepressant such as an SSRI. If combined, monitor cognition, heart rate and anticholinergic effects.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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