Drug interactions
Clomipramine + Ganaxolone
Severity: Moderate
Clomipramine and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a sedating neuroactive steroid, and clomipramine also causes sedation. Combined use may increase somnolence and impair alertness.
What this interaction means in plain words
Clomipramine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation by ganaxolone and sedative effects of clomipramine.
What to do
Monitor for excessive sedation and reduce the dose of either drug if somnolence is troublesome. Advise caution when driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Clomipramine with Ganaxolone?
MediHelp rates the interaction as moderate. Clomipramine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a sedating neuroactive steroid, and clomipramine also causes sedation. Combined use may increase somnolence and impair alertness.
How serious is the interaction between Clomipramine and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the dose of either drug if somnolence is troublesome. Advise caution when driving or operating machinery.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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