Drug interactions
Clomipramine + Glipizide-metformin
Severity: Minor
Clomipramine and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may alter glucose homeostasis, and hypoglycemia has been reported in patients on antidiabetic drugs. Clomipramine could modify the response to glipizide and metformin, though evidence is limited.
What this interaction means in plain words
Clomipramine and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible additive pharmacodynamic effect on glucose; mechanism is not well established.
What to do
Monitor blood glucose when clomipramine is started or stopped and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Glipizide-metformin?
MediHelp rates the interaction as minor. Clomipramine and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may alter glucose homeostasis, and hypoglycemia has been reported in patients on antidiabetic drugs. Clomipramine could modify the response to glipizide and metformin, though evidence is limited.
How serious is the interaction between Clomipramine and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when clomipramine is started or stopped and adjust antidiabetic doses as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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