Drug interactions
Clomipramine + Ibuprofen
Severity: Moderate
Clomipramine and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine, a potent serotonin reuptake inhibitor, combined with ibuprofen increases the risk of bleeding, particularly from the upper gastrointestinal tract.
What this interaction means in plain words
Clomipramine and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Ibuprofen belongs to Musculoskeletal.
Why it happens
Impaired serotonin-dependent platelet aggregation from clomipramine adds to NSAID platelet inhibition and mucosal injury.
What to do
Prefer paracetamol when possible. If an NSAID is needed, use the lowest dose briefly, consider gastroprotection with a proton pump inhibitor, and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Ibuprofen?
MediHelp rates the interaction as moderate. Clomipramine and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine, a potent serotonin reuptake inhibitor, combined with ibuprofen increases the risk of bleeding, particularly from the upper gastrointestinal tract.
How serious is the interaction between Clomipramine and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol when possible. If an NSAID is needed, use the lowest dose briefly, consider gastroprotection with a proton pump inhibitor, and watch for bleeding.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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