Drug interactions
Clomipramine + Isoflurane
Severity: Moderate
Clomipramine and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and cause hypotension, and clomipramine can also affect cardiac conduction and repolarisation. During anaesthesia in patients taking tricyclics, arrhythmias and blood pressure instability are more likely.
What this interaction means in plain words
Clomipramine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarisation and conduction, plus additive hypotensive and autonomic effects.
What to do
Inform the anaesthesia team about tricyclic use and monitor ECG and blood pressure perioperatively. Correct electrolyte abnormalities and avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Clomipramine with Isoflurane?
MediHelp rates the interaction as moderate. Clomipramine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and cause hypotension, and clomipramine can also affect cardiac conduction and repolarisation. During anaesthesia in patients taking tricyclics, arrhythmias and blood pressure instability are more likely.
How serious is the interaction between Clomipramine and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anaesthesia team about tricyclic use and monitor ECG and blood pressure perioperatively. Correct electrolyte abnormalities and avoid other QT-prolonging drugs where possible.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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