Drug interactions
Clomipramine + Lofexidine
Severity: Major
Clomipramine and Lofexidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and hypotension, and lofexidine may prolong the QT interval, as can clomipramine. Tricyclic antidepressants may also reduce the effect of centrally acting alpha-2 agonists.
What this interaction means in plain words
Clomipramine and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
Why it happens
Additive sedation, hypotension and QT effects; tricyclic alpha-2 antagonism may oppose lofexidine.
What to do
Avoid the combination if possible; otherwise monitor ECG, blood pressure and heart rate, and correct electrolytes. Watch for reduced withdrawal symptom control.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Clomipramine with Lofexidine?
MediHelp rates the interaction as major. Clomipramine and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause sedation and hypotension, and lofexidine may prolong the QT interval, as can clomipramine. Tricyclic antidepressants may also reduce the effect of centrally acting alpha-2 agonists.
How serious is the interaction between Clomipramine and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor ECG, blood pressure and heart rate, and correct electrolytes. Watch for reduced withdrawal symptom control.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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