Drug interactions
Clomipramine + Meloxicam
Severity: Moderate
Clomipramine and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a potent serotonin reuptake inhibitor and, with an NSAID, raises the risk of gastrointestinal and other bleeding. The effect is additive with the NSAID's own GI toxicity.
What this interaction means in plain words
Clomipramine and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Meloxicam belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin uptake impairs aggregation, adding to NSAID COX-1 inhibition and mucosal injury.
What to do
Monitor for bleeding signs and consider gastroprotection with a proton pump inhibitor. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Meloxicam?
MediHelp rates the interaction as moderate. Clomipramine and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a potent serotonin reuptake inhibitor and, with an NSAID, raises the risk of gastrointestinal and other bleeding. The effect is additive with the NSAID's own GI toxicity.
How serious is the interaction between Clomipramine and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and consider gastroprotection with a proton pump inhibitor. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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