Drug interactions
Clomipramine + Metformin-pioglitazone
Severity: Minor
Clomipramine and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants like clomipramine may alter glycemic control and have occasionally been linked to hypoglycemia with antidiabetic drugs. The effect is inconsistent and usually small.
What this interaction means in plain words
Clomipramine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Possible additive glucose-lowering effect; the mechanism is not well established.
What to do
Monitor blood glucose when clomipramine is started or stopped and adjust antidiabetic therapy only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Clomipramine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants like clomipramine may alter glycemic control and have occasionally been linked to hypoglycemia with antidiabetic drugs. The effect is inconsistent and usually small.
How serious is the interaction between Clomipramine and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when clomipramine is started or stopped and adjust antidiabetic therapy only if control changes.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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