Drug interactions
Clomipramine + Naproxen
Severity: Moderate
Clomipramine and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a potent serotonin reuptake inhibitor that reduces platelet serotonin, and naproxen impairs platelet function and damages the gastric mucosa. Gastrointestinal bleeding risk is increased.
What this interaction means in plain words
Clomipramine and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Naproxen belongs to Musculoskeletal.
Why it happens
Additive platelet dysfunction from serotonin reuptake inhibition and NSAID COX-1 inhibition with mucosal injury.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Naproxen?
MediHelp rates the interaction as moderate. Clomipramine and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a potent serotonin reuptake inhibitor that reduces platelet serotonin, and naproxen impairs platelet function and damages the gastric mucosa. Gastrointestinal bleeding risk is increased.
How serious is the interaction between Clomipramine and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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