Drug interactions
Clomipramine + Nelfinavir
Severity: Moderate
Clomipramine and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may raise clomipramine concentrations, increasing tricyclic toxicity such as sedation, anticholinergic effects, seizures and QT prolongation. Nelfinavir also inhibits CYP2C19 to some extent.
What this interaction means in plain words
Clomipramine and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Nelfinavir belongs to Anti Virals.
Why it happens
Nelfinavir inhibits CYP3A4 metabolism of clomipramine.
What to do
Monitor for tricyclic adverse effects and consider an ECG. Reduce the clomipramine dose or check levels if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Clomipramine with Nelfinavir?
MediHelp rates the interaction as moderate. Clomipramine and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and may raise clomipramine concentrations, increasing tricyclic toxicity such as sedation, anticholinergic effects, seizures and QT prolongation. Nelfinavir also inhibits CYP2C19 to some extent.
How serious is the interaction between Clomipramine and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider an ECG. Reduce the clomipramine dose or check levels if toxicity appears.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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