Drug interactions
Clomipramine + Oxybutynin
Severity: Moderate
Clomipramine and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine has strong anticholinergic properties, so adding oxybutynin increases the burden of antimuscarinic effects such as dry mouth, constipation, urinary retention, tachycardia and cognitive impairment. Elderly patients are especially vulnerable.
What this interaction means in plain words
Clomipramine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for urinary retention, constipation and confusion, and use the lowest effective doses. Consider an alternative bladder agent or antidepressant in susceptible patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Oxybutynin?
MediHelp rates the interaction as moderate. Clomipramine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine has strong anticholinergic properties, so adding oxybutynin increases the burden of antimuscarinic effects such as dry mouth, constipation, urinary retention, tachycardia and cognitive impairment. Elderly patients are especially vulnerable.
How serious is the interaction between Clomipramine and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and confusion, and use the lowest effective doses. Consider an alternative bladder agent or antidepressant in susceptible patients.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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