Drug interactions
Clomipramine + Pazopanib
Severity: Major
Clomipramine and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib can prolong the QT interval and cause torsades de pointes, and clomipramine also affects cardiac repolarisation. Pazopanib inhibits CYP2D6 and may raise clomipramine levels, further increasing risk.
What this interaction means in plain words
Clomipramine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation with possible CYP2D6 and CYP3A4 inhibition raising clomipramine exposure.
What to do
Avoid if possible; otherwise monitor ECG and electrolytes at baseline and periodically. Consider an alternative antidepressant with lower QT risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Clomipramine with Pazopanib?
MediHelp rates the interaction as major. Clomipramine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib can prolong the QT interval and cause torsades de pointes, and clomipramine also affects cardiac repolarisation. Pazopanib inhibits CYP2D6 and may raise clomipramine levels, further increasing risk.
How serious is the interaction between Clomipramine and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG and electrolytes at baseline and periodically. Consider an alternative antidepressant with lower QT risk.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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