Drug interactions
Clomipramine + Pitolisant
Severity: Moderate
Clomipramine and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant works by increasing histamine release through H3 antagonism, and clomipramine has strong H1 antagonist activity that can counteract this. Pitolisant efficacy may be reduced, and both drugs may affect QT interval.
What this interaction means in plain words
Clomipramine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Pitolisant belongs to Central Nervous System.
Why it happens
Central H1 receptor blockade by clomipramine opposes the histaminergic effect of pitolisant.
What to do
Monitor for loss of wakefulness benefit and consider an alternative antidepressant with less antihistaminic activity. Check ECG if other QT-prolonging risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Clomipramine with Pitolisant?
MediHelp rates the interaction as moderate. Clomipramine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant works by increasing histamine release through H3 antagonism, and clomipramine has strong H1 antagonist activity that can counteract this. Pitolisant efficacy may be reduced, and both drugs may affect QT interval.
How serious is the interaction between Clomipramine and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of wakefulness benefit and consider an alternative antidepressant with less antihistaminic activity. Check ECG if other QT-prolonging risks exist.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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