Drug interactions
Clomipramine + Pseudoephedrine
Severity: Moderate
Clomipramine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pseudoephedrine releases norepinephrine, and clomipramine blocks its reuptake and neuronal uptake of indirect sympathomimetics, producing unpredictable pressor effects. Hypertension, tachycardia and arrhythmias may occur, especially in patients with cardiovascular disease.
What this interaction means in plain words
Clomipramine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Pseudoephedrine belongs to Respiratory.
Why it happens
Tricyclic blockade of norepinephrine reuptake and uptake of indirect sympathomimetics alters adrenergic response.
What to do
Avoid pseudoephedrine in patients with hypertension or heart disease. Otherwise monitor blood pressure and heart rate and use the lowest dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Clomipramine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pseudoephedrine releases norepinephrine, and clomipramine blocks its reuptake and neuronal uptake of indirect sympathomimetics, producing unpredictable pressor effects. Hypertension, tachycardia and arrhythmias may occur, especially in patients with cardiovascular disease.
How serious is the interaction between Clomipramine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pseudoephedrine in patients with hypertension or heart disease. Otherwise monitor blood pressure and heart rate and use the lowest dose for the shortest time.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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