Drug interactions
Clomipramine + Repaglinide
Severity: Minor
Clomipramine and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have been associated with changes in glucose control, and a small additive glucose-lowering effect with insulin secretagogues is conceivable. The clinical relevance with repaglinide is uncertain and data are sparse.
What this interaction means in plain words
Clomipramine and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Possible additive pharmacodynamic effect on glucose homeostasis; not well established.
What to do
No routine change is needed; check blood glucose when clomipramine is started or stopped in a patient on repaglinide, and review the repaglinide dose if readings shift.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Clomipramine with Repaglinide?
MediHelp rates the interaction as minor. Clomipramine and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have been associated with changes in glucose control, and a small additive glucose-lowering effect with insulin secretagogues is conceivable. The clinical relevance with repaglinide is uncertain and data are sparse.
How serious is the interaction between Clomipramine and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check blood glucose when clomipramine is started or stopped in a patient on repaglinide, and review the repaglinide dose if readings shift.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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