Drug interactions
Clomipramine + Salbutamol
Severity: Moderate
Clomipramine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may potentiate cardiovascular effects of beta-agonists, including tachycardia and arrhythmia. Clomipramine also prolongs QT and can lower seizure threshold.
What this interaction means in plain words
Clomipramine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Salbutamol belongs to Respiratory.
Why it happens
Tricyclic inhibition of norepinephrine reuptake enhances adrenergic effects, with additive QT effects.
What to do
Monitor heart rate, rhythm and blood pressure, and keep salbutamol at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Salbutamol?
MediHelp rates the interaction as moderate. Clomipramine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may potentiate cardiovascular effects of beta-agonists, including tachycardia and arrhythmia. Clomipramine also prolongs QT and can lower seizure threshold.
How serious is the interaction between Clomipramine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, and keep salbutamol at the lowest effective dose.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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