Drug interactions
Clomipramine + Scopolamine
Severity: Moderate
Clomipramine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine has marked anticholinergic activity and combining it with scopolamine produces additive antimuscarinic effects. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and may precipitate acute angle-closure glaucoma or ileus in susceptible patients.
What this interaction means in plain words
Clomipramine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic effects such as urinary retention, constipation and cognitive changes, especially in older adults. Reduce the dose or choose an alternative if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Scopolamine?
MediHelp rates the interaction as moderate. Clomipramine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine has marked anticholinergic activity and combining it with scopolamine produces additive antimuscarinic effects. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and may precipitate acute angle-closure glaucoma or ileus in susceptible patients.
How serious is the interaction between Clomipramine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, constipation and cognitive changes, especially in older adults. Reduce the dose or choose an alternative if toxicity develops.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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