Drug interactions
Clomipramine + Sorafenib
Severity: Moderate
Clomipramine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Clomipramine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Perform a baseline and periodic ECG and keep potassium and magnesium in the normal range. Consider an alternative antidepressant in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Clomipramine with Sorafenib?
MediHelp rates the interaction as moderate. Clomipramine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte abnormalities or heart disease.
How serious is the interaction between Clomipramine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline and periodic ECG and keep potassium and magnesium in the normal range. Consider an alternative antidepressant in patients with other QT risk factors.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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