Drug interactions
Clomipramine + Suvorexant
Severity: Moderate
Clomipramine and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so together they can increase daytime drowsiness, impaired psychomotor performance and next-day impairment including driving.
What this interaction means in plain words
Clomipramine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and the sedative effects of clomipramine.
What to do
Start suvorexant at the lowest dose and reassess need, avoiding alcohol and other sedatives. Warn patients about impaired alertness the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Clomipramine with Suvorexant?
MediHelp rates the interaction as moderate. Clomipramine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so together they can increase daytime drowsiness, impaired psychomotor performance and next-day impairment including driving.
How serious is the interaction between Clomipramine and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at the lowest dose and reassess need, avoiding alcohol and other sedatives. Warn patients about impaired alertness the next day.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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