Drug interactions
Clomipramine + Tolmetin
Severity: Moderate
Clomipramine and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a potent serotonin reuptake inhibitor, so with an NSAID it can add to the risk of upper gastrointestinal bleeding. The risk is higher in older patients and those with ulcer history.
What this interaction means in plain words
Clomipramine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Tolmetin belongs to Musculoskeletal.
Why it happens
Clomipramine reduces platelet serotonin uptake and function, adding to the COX-1 mediated antiplatelet and mucosal-damaging effects of tolmetin.
What to do
Use the lowest effective NSAID dose for the shortest duration and consider gastroprotection with a proton pump inhibitor. Watch for signs of GI bleeding and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Tolmetin?
MediHelp rates the interaction as moderate. Clomipramine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a potent serotonin reuptake inhibitor, so with an NSAID it can add to the risk of upper gastrointestinal bleeding. The risk is higher in older patients and those with ulcer history.
How serious is the interaction between Clomipramine and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest duration and consider gastroprotection with a proton pump inhibitor. Watch for signs of GI bleeding and anemia.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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