Drug interactions
Clomipramine + Tolterodine
Severity: Moderate
Clomipramine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is strongly anticholinergic and is also a CYP2D6 substrate and inhibitor. Together with tolterodine it increases the risk of urinary retention, constipation, dry mouth and confusion, and tolterodine exposure may rise.
What this interaction means in plain words
Clomipramine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects with possible CYP2D6 inhibition by clomipramine.
What to do
Monitor for anticholinergic adverse effects and cognitive changes, and reduce the tolterodine dose if they occur. Avoid in older patients when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Tolterodine?
MediHelp rates the interaction as moderate. Clomipramine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is strongly anticholinergic and is also a CYP2D6 substrate and inhibitor. Together with tolterodine it increases the risk of urinary retention, constipation, dry mouth and confusion, and tolterodine exposure may rise.
How serious is the interaction between Clomipramine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and cognitive changes, and reduce the tolterodine dose if they occur. Avoid in older patients when possible.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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