Drug interactions
Clomipramine + Trospium
Severity: Moderate
Clomipramine and Trospium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a strongly anticholinergic tricyclic antidepressant, and combining it with trospium increases antimuscarinic burden. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
What this interaction means in plain words
Clomipramine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Trospium belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects of trospium and clomipramine.
What to do
Monitor for urinary retention, constipation, and cognitive or visual symptoms, particularly in older adults. Reduce the dose or choose a less anticholinergic option if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Trospium?
MediHelp rates the interaction as moderate. Clomipramine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a strongly anticholinergic tricyclic antidepressant, and combining it with trospium increases antimuscarinic burden. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
How serious is the interaction between Clomipramine and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, and cognitive or visual symptoms, particularly in older adults. Reduce the dose or choose a less anticholinergic option if effects emerge.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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