Drug interactions
Clomipramine + Zuranolone
Severity: Moderate
Clomipramine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes CNS depression and impaired psychomotor performance, and clomipramine adds sedation. The combination can worsen drowsiness, dizziness and impaired driving ability.
What this interaction means in plain words
Clomipramine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Consider reducing the zuranolone dose if sedation occurs. Counsel patients not to drive or operate machinery for at least 12 hours after each dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Clomipramine with Zuranolone?
MediHelp rates the interaction as moderate. Clomipramine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes CNS depression and impaired psychomotor performance, and clomipramine adds sedation. The combination can worsen drowsiness, dizziness and impaired driving ability.
How serious is the interaction between Clomipramine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if sedation occurs. Counsel patients not to drive or operate machinery for at least 12 hours after each dose.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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