Drug interactions
Clonazepam + Dexchlorpheniramine
Severity: Moderate
Clonazepam and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine that adds to the drowsiness and psychomotor impairment of clonazepam. Older adults are at higher risk of confusion and falls.
What this interaction means in plain words
Clonazepam and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from central H1 blockade and GABA-A potentiation.
What to do
Advise avoiding driving and alcohol, and consider a non-sedating antihistamine instead. Monitor older patients for confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Clonazepam with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Clonazepam and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a sedating antihistamine that adds to the drowsiness and psychomotor impairment of clonazepam. Older adults are at higher risk of confusion and falls.
How serious is the interaction between Clonazepam and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding driving and alcohol, and consider a non-sedating antihistamine instead. Monitor older patients for confusion and falls.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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