Drug interactions
Clonazepam + Lonafarnib
Severity: Moderate
Clonazepam and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may increase clonazepam levels, causing excessive sedation and respiratory depression. The effect is expected because clonazepam is partly cleared by CYP3A4.
What this interaction means in plain words
Clonazepam and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib strongly inhibits CYP3A4, reducing clonazepam metabolism.
What to do
Monitor for sedation and consider reducing the clonazepam dose during lonafarnib treatment. Adjust again when lonafarnib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Clonazepam with Lonafarnib?
MediHelp rates the interaction as moderate. Clonazepam and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may increase clonazepam levels, causing excessive sedation and respiratory depression. The effect is expected because clonazepam is partly cleared by CYP3A4.
How serious is the interaction between Clonazepam and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and consider reducing the clonazepam dose during lonafarnib treatment. Adjust again when lonafarnib is stopped.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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